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- drugbank:DB05864 type drugbank_vocabulary:Drug assertion.
- drugbank:DB05864 label "PPI-2458 [drugbank:DB05864]" assertion.
- drugbank:DB05864 seeAlso DB05864 assertion.
- drugbank:DB05864 description "PPI-2458 represents a potentially new and important addition to the growing list of therapeutics aimed at specific molecular oncology targets. PPI-2458 is a novel, proprietary molecule belonging to the fumagillin class of compounds that specifically targets the MetAP-2 enzyme. This class of compounds has been shown to prevent both abnormal cell growth and the formation of new blood vessels (known as angiogenesis), which contribute to the growth of aberrant tissues in diseases such as cancer and rheumatoid arthritis. Clinical development with previous fumagillin derivatives has been limited by their toxicity profile. In preclinical studies to date, PPI-2458 has demonstrated the potent pharmacologic activity of this class of compounds while displaying an improved pharmacokinetic and toxicity profile." assertion.
- drugbank:DB05864 identifier "drugbank:DB05864" assertion.
- drugbank:DB05864 title "PPI-2458" assertion.
- drugbank:DB05864 drugbank_vocabulary:x-pubchemcompound pubchem.compound:6918653 assertion.
- drugbank:DB05864 drugbank_vocabulary:x-chemspider chemspider:5293846 assertion.
- drugbank:DB05864 drugbank_vocabulary:x-cas cas: assertion.
- drugbank:DB05864 drugbank_vocabulary:drugbank-id "DB05864" assertion.
- drugbank:DB05864 bio2rdf_vocabulary:x-identifiers.org DB05864 assertion.
- drugbank:DB05864 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB05864" assertion.
- drugbank:DB05864 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB05864 bio2rdf_vocabulary:identifier "DB05864" assertion.