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- drugbank:DB08898 type drugbank_vocabulary:Drug assertion.
- drugbank:DB08898 label "Glucarpidase [drugbank:DB08898]" assertion.
- drugbank:DB08898 seeAlso voraxaze-drug.htm assertion.
- drugbank:DB08898 seeAlso glucarpidase.html assertion.
- drugbank:DB08898 seeAlso DB08898 assertion.
- drugbank:DB08898 description "Glucarpidase is the recombinant form of the Pseudomonas sp. (strain RS-16) enzyme carboxypeptidase G2 that is produced in Escherichia coli. In patients, glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. Therefore since methotrexate is eliminated enzymatically and not by the kidneys, glucarpidase is indicated in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (>1 micromole per liter). Glucarpidase is marketed under the brand name Voraxaze®." assertion.
- drugbank:DB08898 identifier "drugbank:DB08898" assertion.
- drugbank:DB08898 title "Glucarpidase" assertion.
- drugbank:DB08898 drugbank_vocabulary:x-cas cas:9074-87-7 assertion.
- drugbank:DB08898 drugbank_vocabulary:drugbank-id "DB08898" assertion.
- drugbank:DB08898 bio2rdf_vocabulary:x-identifiers.org DB08898 assertion.
- drugbank:DB08898 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB08898" assertion.
- drugbank:DB08898 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB08898 bio2rdf_vocabulary:identifier "DB08898" assertion.
- drugbank:DB08898 drugbank_vocabulary:x-wikipedia wikipedia:Glucarpidase assertion.
- drugbank:DB08898 drugbank_vocabulary:x-kegg kegg:D10260 assertion.
- drugbank:DB08898 drugbank_vocabulary:x-atc atc:V03AF09 assertion.
- drugbank:DB08898 drugbank_vocabulary:x-ndc ndc:50633-210-11 assertion.
- drugbank:DB08898 drugbank_vocabulary:x-uniprot uniprot:P06621 assertion.