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- drugbank:DB09024 type drugbank_vocabulary:Drug assertion.
- drugbank:DB09024 label "Follitropin Alpha [drugbank:DB09024]" assertion.
- drugbank:DB09024 seeAlso DB09024 assertion.
- drugbank:DB09024 description "Follitropin alpha is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin alpha was the worldâs first recombinant human FSH preparation and is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature âalphaâ differentiates it from another recombinant human FSH product that was marketed later as follitropin beta. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH." assertion.
- drugbank:DB09024 identifier "drugbank:DB09024" assertion.
- drugbank:DB09024 title "Follitropin Alpha" assertion.
- drugbank:DB09024 drugbank_vocabulary:x-cas cas:56832-30-5 assertion.
- drugbank:DB09024 drugbank_vocabulary:drugbank-id "DB09024" assertion.
- drugbank:DB09024 bio2rdf_vocabulary:x-identifiers.org DB09024 assertion.
- drugbank:DB09024 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB09024" assertion.
- drugbank:DB09024 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB09024 bio2rdf_vocabulary:identifier "DB09024" assertion.