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- source_evidence_literature type ECO_0000212 NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- befree-2016 importedOn "2016-02-19" NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_assertion wasGeneratedBy ECO_0000203 NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_assertion wasDerivedFrom befree-2016 NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_assertion SIO_000772 12454817 NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_assertion evidence source_evidence_literature NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.
- NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_assertion description "[We conclude (1) that p16(INK4a) epigenetic inactivation most likely represents an early event, insufficient for malignant transformation, that may occur in clinically benign lesions such as LS; (2) that lack of pRb was only detected in fewer than one quarter of the carcinomas and could be considered a late secondary event; and (3) that cyclin-D1, which was overexpressed in VC and VIN, could contribute to the malignant transformation in association with p16 hypermethylation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP375902.RAbnP7knjtwWjn_O6wU_-li1WtKJwotdhgphLsxJbPNd8130_provenance.