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- _4 label "Selventa" provenance.
- _4 comment "support@belframework.org" provenance.
- small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
- small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
- small_corpus.bel version "1.6" provenance.
- small_corpus.bel authoredBy _4 provenance.
- assertion wasDerivedFrom _3 provenance.
- assertion wasDerivedFrom small_corpus.bel provenance.
- assertion hadPrimarySource 18705745 provenance.
- _3 wasQuotedFrom 18705745 provenance.
- _3 value "Cationic amphiphilic drugs such as amiodarone, perhexiline, diethylaminoethoxyhexestrol (DEAEH) and tamoxifen can be first protonated in the intermembrane space of mitochondria, and then electrophoretically transported into the mitochondrial matrix thanks to the Δψm [3,4,40,42], as discussed in greater detail below. This transfer across the inner mitochondrial membrane dissipates Δψm (Figure 1) and increases the basal (state 4) mitochondrial respiration. This phenomenon, which is called 'OXPHOS uncoupling', can also be observed in the case of some mitochondrial poisons such as the protonophores 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP)." provenance.
- small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
- small_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." provenance.