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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 15247412 provenance.
- _4 wasQuotedFrom 15247412 provenance.
- _4 value "At 4 weeks of age, in the fed state, Ncb5or -/- mice had normal blood glucose levels (Fig. 2a) but insulin levels were 40% those of wild-type littermates (Fig. 2b). These animals had impaired tolerance to an i.p. injection of glucose (Fig. 2c), suggesting decreased insulin reserve, i.e., prediabetes. By 7 weeks of age, the blood glucose levels in Ncb5or -/- mice were 3-fold higher than those in +/+ mice during the fed state or after an overnight fast (Fig. 2a). The hyperglycemia in the Ncb5or -/- animals was associated with a marked reduction in plasma insulin. In the fed state, insulin levels of 7-week-old Ncb5or -/- animals were decreased to 25% of the levels in normal animals (Fig. 2b). Insulin was barely detectable in the plasma of fasting Ncb5or -/- animals (data not shown). These data indicate that, between 4 and 7 weeks of age, there was a progressive deterioration of glucose homeostasis in Ncb5or -/- mice." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.