Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RA3iMxarALZDZ8Dy2VYFPzJpBgoR8wnjNP3R4bYKkTnqc#provenance>. }

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_4 label "Selventa" provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
large_corpus.bel version "20131211" provenance.
large_corpus.bel authoredBy _4 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _3 provenance.
assertion hadPrimarySource 11841347 provenance.
_3 wasQuotedFrom 11841347 provenance.
_3 value "Precise temporal and spatial coordination of proteolytic and nonproteolytic mechanisms is responsible for the succession of events during cell migration. With a non-proteolytic mechanism, uPA would stimulate cell migration by enhancing adhesion at the leading edge, through stimulation of binding of uPAR to vitronectin, modulation of uPAR/integrin interaction and/or by initiation of signal-transduction cascade that results in the cytoskeleton reorganization and in the cell \"dragging up\" to the leading edge. The proteolytic mechanisms include uPA catalyzed plasmin generation at focal adhesion sites that results in extracellular matrix degradation and thus facilitate detachment of the trailing edge. Both mechanisms could be operating simultaneously in the individual migrating cell. The role of PAI-1 in migration depends on its pericellular localization. The anti-migrational effect of PAI-1 seems to be associated with suppression of plasmin generation on the ventral surface of the cell, preventing its unfastening, with an inhibition of vitronectin binding to integrins and to uPAR on the leading edge." provenance.