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- _6 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion hadPrimarySource 19966300 provenance.
- _5 wasQuotedFrom 19966300 provenance.
- _5 value "In agreement with the role of S62 phosphorylation on reporter gene expression, the hTERT and Bmi-1 genes were repressed by IFN-? + TPA and by the Cdk2 inhibitor CVT-313 (Fig. 6D), whereas the p21 and p16Ink4A genes were strongly induced (Fig. 6E). The changes in gene expression are consistent with the ChIP results and indicate that cyclin E/Cdk2 enhances, whereas IFN-?, through the activation of p27, represses Myc-activated transcription (and vice versa for Myc-repressed transcription) of genes involved in cellular senescence. " provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.