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- _7 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _7 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _6 provenance.
- assertion hadPrimarySource 19842832 provenance.
- _6 wasQuotedFrom 19842832 provenance.
- _6 value "CSM-induced activation of TLR-4 has been shown to induce IRAK1 phosphorylation and TRAF6 degradation. An increase in IkB phosphorylation and degradation is also observed which ultimately leads to the translocation of NF-kB (p65) into the nucleus. The ability of cigarette smoke condensate (CSC) to activate NF-kB has also been demonstrated in another study using U937 cells. CSC has been shown to induce the activation of IKK (-a and -b) at 15 minutes post treatment, which resulted in increased phosphorylation of I?-B? at serine 32, resulting in Ik-Ba degradation and subsequent activation of NF-kB [53]." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.