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- _7 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _7 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _6 provenance.
- assertion hadPrimarySource 11792802 provenance.
- _6 wasQuotedFrom 11792802 provenance.
- _6 value "The Smurfs can also regulate ubiquitination and degradation of other target proteins, including the TGF-b receptor complex and the transcriptional co-repressor SnoN (Bonni et al., 2001; Ebisawa et al., 2001; Kavsak et al., 2000; Stroschein et al., 2001) (Fig. 7). Smurf1 and Smurf2 associate with the nuclear I-Smad Smad7 after stimulation by TGF-b (Ebisawa et al., 2001; Kavsak et al., 2000). The I-Smad-Smurf complex is exported to the cytoplasm and ubiquitinates the receptors on the cell surface or endosomal membranes; these are then targeted for degradation in proteasomes and lysosomes." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.