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- _6 label "Selventa" provenance.
- _6 comment "support@belframework.org" provenance.
- small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
- small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
- small_corpus.bel version "1.6" provenance.
- small_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion wasDerivedFrom small_corpus.bel provenance.
- assertion hadPrimarySource 11035810 provenance.
- _5 wasQuotedFrom 11035810 provenance.
- _5 value "PI3K-dependent activation of PKB is an intermediary in the phosphorylation and inactivation of GSK-3 induced by insulin and other growth factors (10, 12, 14). Insulin and IGF-1 efficiently activate the PI3K pathway in NIH 3T3 and Rat1 cells, respectively. GSK-3 phosphorylation induced by insulin and IGF-1 were eliminated by pretreatment with the PI3K inhibitors wortmannin or LY294002. In contrast, the effects of 8-Br-cAMP or forskolin on GSK-3 phosphorylation in these cell lines were not altered by inhibition of PI3K activity with wortmannin or LY294002 (Fig. 2A), excluding the possibility that PKA induces GSK-3 phosphorylation through activation of PI3K." provenance.
- small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
- small_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." provenance.