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- _7 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _7 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _6 provenance.
- assertion hadPrimarySource 11448946 provenance.
- _6 wasQuotedFrom 11448946 provenance.
- _6 value "TNF? also induced in HUVEC, a marked time- and dose-dependent stimulation of SAPK2/p38 that is characterized by an increased activity of MAPKAP K2/3, a direct physiological target of SAPK2/p38 (21). Maximal stimulation was obtained after a 10-min exposure to concentrations of TNFalpha equal to or higher than 5 ng/ml (Fig. 3,A and B). The pyridinylimidazole derivative SB203580, in concentrations of 1?5 ?m, completely inhibited the TNFalpha-induced increase in SAPK2/p38 activity as reflected by the inhibition of MAPKAP K2/3 activation in cells exposed to TNFalpha (Fig. 3 C). " provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.