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- _10 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _10 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _9 provenance.
- assertion hadPrimarySource 17210675 provenance.
- _9 wasQuotedFrom 17210675 provenance.
- _9 value "Lysophosphatidic acid (LPA) induced mTOR was shown to be dependent on PLD1 and Rho (17). The activation of mTOR by Cdc42 was also dependent on PLD1 (18). Suppression of PLD1 expression blocked S6 kinase phosphorylation in B16 melanoma cells, and suppression of either PLD1 or mTOR led to melanogenesis in these cells (19). Very recently, it was reported that PLD2 forms a functional complex with mTOR and its binding partner Raptor (known as mTORC1) through a TOS (TOR signaling) motif in PLD2 (21). The interaction between mTORC1 and PLD2 was essential for mitogen stimulation of mTOR(21). Thus, in addition to the ability of PA to activate mTOR, there are several studies that have shown a PLD requirement for the activation of mTOR." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.