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- _6 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion hadPrimarySource 16325763 provenance.
- _5 wasQuotedFrom 16325763 provenance.
- _5 value "IL-18 treatment markedly increased phospho-ATF-2 (Thr71) levels in HCMEC, and this effect was blocked by the IL-18BPa/Fc chimera (Fig. 5A). Furthermore, treatment with the p38PMAPK inhibitor SB203580 strongly inhibited IL-18-mediated ATF-2 phosphorylation (Fig. 5B). Inhibition of p38MAPK also attenuated p65 phosphorylation (Fig. 5C) and NF-?B-driven reporter gene activity (Fig. 5D). Together, these results demonstrate that IL-18 induced NF-?B activation via p38MAPK activation (Fig. 5)." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.