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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 18270325 provenance.
- _4 wasQuotedFrom 18270325 provenance.
- _4 value "Our previous studies showed that etoposide may induce an apoptotic signaling pathway similar to that induced by ceramide.15,16 We thus determined the generation of ceramide in etoposide-treated Jurkat T cells. Results showed that etoposide induced ceramide generation within 1 hour (Figure 4A). Treatment with fumonisin B1, an inhibitor of ceramide synthase, and myriocin, an inhibitor of serine palmitoyl transferase {SPTLC1, SPTLC2}, but not chlorpromazine and desprimine, inhibitors of acid sphingomyelinase, inhibited etoposide-induced cell apoptosis (Figure 4B), thus indicating a requirement for de novo ceramide generation. Furthermore, we demonstrated the increased expression of Txnip by etoposide (Figure 4C) " provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.