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- _6 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion hadPrimarySource 16034410 provenance.
- _5 wasQuotedFrom 16034410 provenance.
- _5 value "Conversely, insulin-stimulated PI(3)K activity was increased by 80% in muscle of both Rbp+/- and Rbp4-/- mice compared with control mice (Fig. 5b). However, PI(3)K activity was not altered in the liver of RBP4-Tg (Fig. 5c) or Rbp4-/- mice (Fig. 5d). Consistent with these observations, RBP4 injection for 21 days in wild-type mice caused a 34% reduction in insulin-stimulated PI(3)K activity in muscle, but no alteration in liver (Fig. 5e). Furthermore, RBP4 treatment resulted in a 24% reduction in insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS1) at tyrosine residue 612 (Fig. 5f), an important docking site for the p85 subunit of PI(3)K23." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.