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- _7 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _7 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _6 provenance.
- assertion hadPrimarySource 14506307 provenance.
- _6 wasQuotedFrom 14506307 provenance.
- _6 value "FIG. 2. Scheme of regulation of the small GTPase RhoA. In the resting state, RhoA GDP exists in the cytosol with its prenylated, hydrophobic tail buried within its partner, GDP dissociation inhibitor (RhoGDI). Activation of receptors coupled to certain trimeric G proteins (Galpha q, Galpha12,13) and receptor Tyr kinases leads, through activity of guanine nucleotide exchange factors (GEFs), to the exchange of GTP for GDP on RhoA. RhoGDI dissociates and RhoA GTP associates with the membrane where it interacts with Rho-kinase (ROK) to initiate signaling cascades. Rho GTPase activating proteins (RhoGAPs) catalyze hydrolysis of GTP bound to RhoA and RhoA GDP reassociates with RhoAGDI." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.