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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 11172729 provenance.
- _4 wasQuotedFrom 11172729 provenance.
- _4 value "Two types of receptors have been identified for FGF-2: high affinity tyrosine-kinase FGF receptors (FGFRs) (123) and low affinity heparan sulfate proteoglycans (HSPGs). Thus far, at least four members of FGFRs have been identified. They represent low number (approx. 10,000 per cell), but high affinity sites (Kd of 20-600 pM). Low affinity binding sites (Kd of 2-20 nM) with high capacity (approx. 1 million sites per cell) were identified as proteoglycans, including syndecan and perlecan, containing heparan sulfate side chains (202). These HSPGs are found in the ECM, the basement membrane and the cell surface. It has been suggested that binding of FGF-2 to HSPGs result in protection of FGF-2 from inactivation in the extracellular environment and in storage of FGF-2 in the ECM and basement membrane." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.