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- _6 label "Selventa" provenance.
- _6 comment "support@belframework.org" provenance.
- small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
- small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
- small_corpus.bel version "20131211" provenance.
- small_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom small_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion hadPrimarySource 17511588 provenance.
- _5 wasQuotedFrom 17511588 provenance.
- _5 value "The mitogenic and chemotactic effects of VEGF in ECs are mediated mainly through VEGFR2 (76). VEGFR2 is activated through ligandstimulated receptor dimerization and transphosphorylation (autophosphorylation) of tyrosine residues in the cytoplasmic kinase domain. At present, tyrosine residues 951 and 996 in the kinase insert domain, and 1054 and 1059 in the kinase catalytic domain, have been identified as autophosphorylation sites for VEGFR2 in a bacterial expression system (30). This event is followed by activation of downstream signaling pathways such as Src, PI3 kinase, MAP kinases, and Akt, which is essential for VEGF-induced actin reorganization, cell migration, and proliferation of ECs." provenance.
- small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
- small_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." provenance.