Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RAS_4zKoNNmcuVDayICRX2DfkdTL0IY_vwAtNY9xMJBGs#provenance>. }

Showing items 1 to 14 of 14 with 100 items per page.

_6 label "Selventa" provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
_4 title "Weizmann Institute open day 2002: cancer research and therapy" provenance.
_4 type "Other" provenance.
_4 identifier "Weizmann Institute open day 2002: cancer research and therapy" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
large_corpus.bel version "20131211" provenance.
large_corpus.bel authoredBy _6 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _5 provenance.
assertion hadPrimarySource _4 provenance.
_5 wasQuotedFrom _4 provenance.
_5 value "E2F up-regulates expression of genes involved in DNA replication, DNA repair and mitosis We use DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data demonstrate that E2F up-regulates the expression of tens of genes not previously described as E2F target genes. Many of these novel E2F-regulated genes code for components of the DNA replication machinery. Among them are the genes coding for replication protein A (RPA). RPA is the most abundant ssDNA binding protein in eukaryotic cells and it plays an essential role in DNA replication. It is a heterotrimer composed of 70kDa (RPA1), 32kDa (RPA2) and 14kDa (RPA 3) subunits and our data show that expression of the genes, coding for these three subunits, is up-regulated by E2F. The regulation of the RPA2 gene was studied in greater detail and we show that it is directly regulated by E2F via E2F-binding sites in its promoter." provenance.