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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 11090623 provenance.
- _4 wasQuotedFrom 11090623 provenance.
- _4 value "Very recent studies have suggested possible connections between Akt, PTEN, and integrin biology. For example, integrin- airlinked kinase (ILK) activation is inhibited by blockade of Akt function (Persad et al., 2000), and PTEN interacts with focal adhesion kinase (FAK) and influences cell migration (Tamura et al., 1999). These interactions affect cell survival, an event influenced by both VEGF and integrins. Also, cell migration and angiogenesis are reg- ulated by Akt and PTEN, and these cellular responses are clearly mediated by integrins (Jiang et al., 2000). By overexpression approaches, we have directly impli- cated Akt and PTEN in the pathway from VEGF to integ- rin activation. Thus, some of the functions of PI 3-kinase, Akt, and PTEN in cell migration may depend upon their role in integrin activation, and engagement of VEGFR2" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.