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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 15066123 provenance.
- _4 wasQuotedFrom 15066123 provenance.
- _4 value "Luciferase reporters carrying 1.8 kb of 5'-flanking region of the mouse CYP8B gene or 0.9 kb of 5'-flanking region of the rat CYP51 gene were constructed (Fig. 5A). The basal transcriptional activity of the CYP8B promoter (Fig. 5B, left panel) was high as compared with that of CYP7A. The addition of hDEC1 had little effect on the basal activity of the CYP8B promoter (Fig. 5B, left panel), whereas hDEC2 and mDEC2 suppressed the basal transcriptional activity of the CYP8B promoter. DBP expression plasmid enhanced the promoter activity by 4-fold (Fig. 5B, right panel). The enhanced transcriptional activity by rDBP was markedly suppressed by hDEC2 or mDEC2, but not by hDEC1. Like CYP8B, the basal transcriptional activity of the CYP51 promoter was high as compared with CYP7A, and was suppressed by hDEC2 or mDEC2 (Fig. 5C). " provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.