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- _6 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion hadPrimarySource 14570040 provenance.
- _5 wasQuotedFrom 14570040 provenance.
- _5 value "the oncogenic effects of Notch include phosphatidylinositol 3-kinase (PI3K) activation and induction of ERBB2 and NF-?B2 expression. The mechanism by which PI3K is activated by NOTCH1-IC is not known, but the induction of ERBB2 and NF-?B2 - the promoters of which contain CSL-binding sites - is almost certainly mediated by the transactivation function of NOTCH1-IC. PI3K signalling confers resistance to anoikis 80,81 and p53-mediated apoptosis 82, whereas ERBB2 stimulates proliferation and growth of cells." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.