Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RAZxl60NEa1KRFtTFBkTspeWxBji2cGpftT5SqAx7UY7U#provenance>. }

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_8 label "Selventa" provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
_6 title "NR0B2 Gene summary" provenance.
_6 type "Other" provenance.
_6 identifier "NR0B2 Gene summary" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
large_corpus.bel version "1.4" provenance.
large_corpus.bel authoredBy _8 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _7 provenance.
assertion hadPrimarySource _6 provenance.
_7 wasQuotedFrom _6 provenance.
_7 value "Entrez Gene summary: Rat: SUMMARY: interacts with peroxisome proliferator-activated receptor alpha (PPAR alpha); can form a dimer with other nuclear hormone receptors [RGD] ... Human: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. OMIM summary: Human: The nuclear receptor superfamily is a group of transcription factors regulated by small hydrophobic hormones such as retinoic acid, thyroid hormone, and steroids. This superfamily also includes orphan nuclear receptors, such as NR0B2, which are related proteins that do not have known ligands ({7:Seol et al., 1996})." provenance.