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- _3 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _3 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _2 provenance.
- assertion hadPrimarySource 14506307 provenance.
- _2 wasQuotedFrom 14506307 provenance.
- _2 value "cAMP and cGMP reduce [Ca2]i and relax smooth muscle through their cAMP- (PKA) and cGMP-activated (PKG) kinases (50, 410, 418). Several effects of cAMP are mediated by cross activation of PKG (50, 104), and significant components of the relaxant effects of cGMP are mediated through Ca2 desensitization (188) (Fig. 6). Inhibition of cAMP-induced Ca2 desensitization by a relatively selective PKG inhibitor also suggests that major effects of both cAMP and cGMP on the Ca2 sensitivity of myosin II are mediated by PKG, rather than PKA, whereas the nitric oxide (NO)-induced decrease in [Ca2]i is independent of PKG (418), and perhaps mediated by PKA cross-activated by cGMP." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.