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_4 label "Selventa" provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
large_corpus.bel version "20131211" provenance.
large_corpus.bel authoredBy _4 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _3 provenance.
assertion hadPrimarySource 14729387 provenance.
_3 wasQuotedFrom 14729387 provenance.
_3 value "Endothelin has been implicated in the pathogenesisof ischemic heart disease and congestive heart failure. The aims were toquantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in humancoronary arteries from patients with ischemic heart disease, congestive heartfailure and controls using real-time polymerase chain reaction (real-time PCR).In addition, the suitability of organ culture as a model mimicking endothelinreceptor changes in cardiovascular disease was evaluated by in vitropharmacology and real-time PCR. Endothelin ETA and ETB receptor mRNA levels weresignificantly higher in arteries from patients with ischemic heart disease(0.23+/-0.04 and 0.35+/-0.06) as compared to congestive heart failure(0.09+/-0.02 and 0.07+/-0.01) and controls (0.08+/-0.02 and 0.08+/-0.01). Afterorgan culture, the endothelin ETB receptor mRNA levels were elevated, and thesarafotoxin 6c-induced vasoconstriction was more efficacious. Increasedendothelin receptor activity may contribute to the increased vascular tone anddevelopment of atherosclerotic disease in ischemic heart disease inman." provenance.