Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RAkdRRHph4atEbPVsUBow0fw8p6TD5hGNgLvROcQs7a8Q#provenance>. }

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_5 label "Selventa" provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
large_corpus.bel version "20131211" provenance.
large_corpus.bel authoredBy _5 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _4 provenance.
assertion hadPrimarySource 15936931 provenance.
_4 wasQuotedFrom 15936931 provenance.
_4 value "The first transcription factors found to participate in adipogenesis were members of the bZIP family of CCAAT/enhancer binding proteins (C/EBPs), specifically C/EBPa, C/EBPb, and C/EBPd. Upon the addition of adipogenic cocktail to 3T3-L1 pre-adipocytes, there is a rapid and transient elevation in C/EBPb and C/EBPd [7,9] The appearance of these proteins is followed rapidly by the expression of C/EBPa, and by the nuclear hormone receptor peroxisome proliferator-activated receptor g (PPARg). These two factors remain elevated for the rest of the differentiation process and indeed for the life of the mature adipocyte. C/EBPa and PPARg are the most critical factors yet discovered for adipogenesis, as will be discussed below. For the moment, suffice it to say that virtually every single downstream target gene whose expression defines the adipocyte appears to be regulated by one or both of these proteins. All of the aforementioned factors, C/EBPa, C/EBPb, C/EBPd, and PPARg, can induce or accelerate differentiation in non-adipogenic NIH-3T3 cells [7]." provenance.