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- _8 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _8 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _7 provenance.
- assertion hadPrimarySource 10322110 provenance.
- _7 wasQuotedFrom 10322110 provenance.
- _7 value "To test whether pRb is required for MyoD to activate the MEF2C TAD, we transfected Rb-/- fibroblasts with the Gal4-MEF2C fusion protein either alone or with MyoD and E12, in either the absence or the presence of exogenous pRb. When expressed alone, MyoD+E12 did not significantly stimulate Gal4-MEF2C function in these cells (Figure 3c, column 4). Similarly, the expression of pRb alone did not affect the activity of Gal4-MEF2C (Figure 3c, column 5); but, the combined expression of MyoD+E12 and pRb led to a 45-fold increase in the activity of Gal4-MEF2C (Figure 3c, column 6). These findings indicate that MyoDmediated activation of the MEF2C TAD requires pRb." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.