Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RAlteRnBdVRaBRcWVLo7M6HzZy-aWj9MLV93-QDdE7Dd8#provenance>. }

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_7 label "Selventa" provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
large_corpus.bel version "20131211" provenance.
large_corpus.bel authoredBy _7 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _6 provenance.
assertion hadPrimarySource 12764228 provenance.
_6 wasQuotedFrom 12764228 provenance.
_6 value "Although CREB thus seems to be an important factor in the induction of PGC-1-alpha , the increased effect of CaMKIV in combination with CnA suggests that factors in addition to CREB are likely to be involved in the transcription of the PGC-1-alpha gene in muscle. Because MEF2 and NFAT transcription factors are known targets of CaMKIV and CnA in muscle fiber-type determination, we tested the role of these factors in the control of the PGC-1-alpha promoter. MEF2C, MEF2D, or NFATc3 alone did not have a significant effect on the function of the 2-kb PGC-1-alpha promoter (Fig. 2A). However, because MEF2 proteins are known to be coactivated by PGC-1-alpha (7), we also tested these factors in cotransfection experiments. As shown in Fig. 2A, a coactivation by PGC-1-alpha of both MEF2C and MEF2D, but not NFAT, was observed on the PGC-1-alpha promoter. These data suggest that PGC-1-alpha might participate in the activation of its own promoter and that the MEF2 proteins may function both in the regulation of PGC-1-alpha expression and as downstream targets of PGC-1-alpha coactivation of other muscle-selective genes." provenance.