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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 17615396 provenance.
- _4 wasQuotedFrom 17615396 provenance.
- _4 value "Shapiro and colleagues (107) demonstrated that MMP-12-null mice are protected from the development of cigarette smoke-induced emphysema. Infiltrating macrophages in wild-type mice exposed to cigarette smoke might have been attracted by elastin fragments released by MMP-12, as MMP-12 knockout mice did not show evidence of increased alveolar macrophage accumulation due to chronic cigarettes smoke inhalation (124). When exposed to cigarette smoke for 2–3 days, MMP-12-null mice had an attenuated number of lung neutrophils and decreased expression of MIP-2, MIP-1{alpha}, and MMP-9 activity in BAL, suggesting that the MMP-9 response is dependent almost entirely on MMP-12 expression (180). " provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.