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- _3 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _3 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _2 provenance.
- assertion hadPrimarySource 15602009 provenance.
- _2 wasQuotedFrom 15602009 provenance.
- _2 value "Macrophages in COPD. Macrophages may play a pivotal role in COPD as they are activated by cigarette smoke extract and secrete many inflammatory proteins that may orchestrate the inflammatory process in COPD. Neutrophils may be attracted by IL-8, GRO-{alpha}, LTB4, MCP-1, and CD8+ lymphocytes by IP-10, Mig, and I-TAC. Release of elastolytic enzymes including MMPs and cathepsins causes elastolysis and release of TGF-{beta}1 and CTGF. Release of TGF-{alpha} activates EGFR, which stimulates mucus hypersecretion. Macrophages also generate ROS and NO, which together form peroxynitrite and may contribute to steroid resistance." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.