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- _4 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _3 provenance.
- assertion hadPrimarySource 15578112 provenance.
- _3 wasQuotedFrom 15578112 provenance.
- _3 value "However, the combination of antibodies to TNFa, IL-6, and IL-1b markedly attenuated LPS induction of resistin (Figure 3C). These data clearly show that resistin induction by endotoxin is mediated by a cascade in which the primary event is secretion of inflammatory cytokines that, in turn, induce resistin. Induction of Resistin Is Blocked by Anti-Inflammatory Insulin-Sensitizing Drugs That Target NF-kB Mouse resistin, produced exclusively by adipocytes, is down-regulated by antidiabetic thiazolidinediones, including rosiglitazone [11]. Consistent with an earlier report [16], rosiglitazone down-regulated resistin gene expression (Figure 4A) in LPS-stimulated human macrophages. Resistin protein secretion was also significantly reduced by rosiglitazone (Figure 4B). Hence, macrophage expression of resistin and its induction by LPS is species-specific, but down-regulation of resistin by thiazolidinedione occurs both in rodents and humans." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.