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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 21461336 provenance.
- _4 wasQuotedFrom 21461336 provenance.
- _4 value "The concentration of cholesterol in cell membranes, including the membrane of the Sarcoplasmic Reticulum/Golgi Apparatus system, is the signal to regulate the connection between the transcription factor, Sterol Regulatory Element Binding Protein (SREBP), and its anchor protein SREBP-Cleavage Activating Protein (SCAP). Cytoplasmic sequestration of SREBP by SCAP prevents the synthesis of LDL-R and other enzymes involved in cholesterol synthesis, especially HMG-CoA-R. The higher the concentration of cholesterol in cell membranes, the greater the inhibition of the synthesis of LDL-R." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.