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- _4 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _3 provenance.
- assertion hadPrimarySource 10194465 provenance.
- _3 wasQuotedFrom 10194465 provenance.
- _3 value "Phosphotyrosine phosphatases (PTPases). PTPases are responsible for dephosphorylation of the insulin receptor and its substrates, and hence, turning off the insulin signal. To date, no insulin receptor-specific phosphatase has been identified. Total membrane-bound tyrosine phosphatase activity is increased in skeletal muscle of type 2 diabetic patients (158). Immunodepletion experiments in muscles from these diabetic patients and obese individuals suggest that especially two phosphatases, protein-tyrosine phosphatase 1B (PTP-1B) and leukocyte antigen-related (LAR) phosphatase, are mainly responsible for this increase (159)." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.