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- _6 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion hadPrimarySource 10322110 provenance.
- _5 wasQuotedFrom 10322110 provenance.
- _5 value "Strikingly, activation of the MEF2 reporter by a fusion protein consisting of MyoD with the herpesvirus VP16 transactivation domain (MyoD-VP16) remained predominantly pRb-dependent (Figure 1b, columns 4 and 5), even though MyoD-VP16 alone activated the E-box reporter considerably more than did wild-type MyoD and pRb together (Figure 1a, columns 3 and 4). Moreover, MyoD-VP16 did not activate the MEF2 reporter to significantly greater levels in either the absence or the presence of pRb than did wild-type MyoD (Figure 1b, compare columns 2 and 3 with columns 4 and 5). Together, these findings indicate that pRb is specifically required for MyoD-mediated activation of MEF2 and that this process is not a direct function of the transactivation abilities of MyoD. MEF2 expression, DNA binding, and nuclear localization are not modulated by pRb" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.