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- _5 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion hadPrimarySource 18073400 provenance.
- _4 wasQuotedFrom 18073400 provenance.
- _4 value "The two main CYP enzymes that are up-regulated by cigarette smoke are CYP1A1 and CYP1B1, which are regulated by ER{alpha} (18). Stimulation of estrogen receptor in the lungs increases protein expression of CYP1A1 by twofold (17). The increased CYP expression is also related to increased estradiol-? expression (19). CYPs are also involved in the bioactivation of 17?-estradiol, resulting in a positive feedback loop" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.