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- _6 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _6 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion hadPrimarySource 10085091 provenance.
- _5 wasQuotedFrom 10085091 provenance.
- _5 value "Kang et al. (1999) demonstrated that the ARA54 gene (RNF14; 605675) can function as a coactivator for androgen-dependent transcription on both wildtype and mutant androgen receptor. They found that in the presence of a certain amount of 17-beta-estradiol or hydroxyflutamide, the transcriptional activity of a specific AR mutant was significantly enhanced, whereas that of wildtype and another AR mutant was not. They therefore suggested that both ARA54 and the positions of the AR mutation might contribute to the specificity of AR-mediated transactivation. Coexpression of ARA54 with other AR coactivators, such as ARA70 (601984) and SRC1 (602691), showed additive stimulation of AR-mediated transactivation, indicating that these cofactors may function individually as AR coactivators to induce AR target gene expression." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.