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- _4 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _3 provenance.
- assertion hadPrimarySource 12975454 provenance.
- _3 wasQuotedFrom 12975454 provenance.
- _3 value "IL-1 was reported to be involved in the feeding suppression caused by leptin, which is released from adipocytes and suppresses food intake through actions in the hypothalamus. IL-1 promotes the release of corticotropin releasing factor (CRF; references 18, 19), melanocortins, and other neuropeptides (4). CRF suppresses feeding behavior when administered intracerebroventricularly. IL-1B selectively destroys the insulin-producing B cells, but not the {alpha} cells, in vitro. This cytotoxic effect of IL-1 is suggested to be mediated by the induction of inducible nitric oxide synthase or prostaglandins On the other hand, it was reported that IL-1 acts as a hypoglycemic agent not only in normal animals but also in alloxan-induced diabetic and genetically diabetic mice (32) and increases insulin and glucagon levels, suggesting that IL-1 has antidiabetic effects (33)" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.