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- _4 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "20131211" provenance.
- large_corpus.bel authoredBy _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _3 provenance.
- assertion hadPrimarySource 12761471 provenance.
- _3 wasQuotedFrom 12761471 provenance.
- _3 value "Theoretically, under hypoxic conditions, the Fe(II) state is favored in preference to Fe(III), which could result in the release of iron from ferritin or other compartments. The increased amount of Fe(II) could result in two effects: (1) It may be incorporated into the [4Fe-4S] cluster of IRP-1 and decrease RNA-binding activity, and (2) it could result in increased IRP-2 degradation. It is notable that oxidant stress has been shown to have both transcriptional and post-transcriptional effects on ferritin expression.2 Indeed, oxidant stress can directly increase the transcription of the ferritin gene.14 For example, this occurs after exposure to agents which decrease glutathione levels that acts as a defense against free radicals.15 Further, oxidant stress can inactivate IRP-1 by oxidizing critical sulfydryl groups of cysteine residues that are important for mRNA binding." provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.