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- _4 label "Selventa" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- large_corpus.bel version "1.4" provenance.
- large_corpus.bel authoredBy _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _3 provenance.
- assertion hadPrimarySource 11287608 provenance.
- _3 wasQuotedFrom 11287608 provenance.
- _3 value "This modification is necessary for the association of BAD with the 14-3-3 proteins, which prevents BAD translocation to the mitochondria and its interaction with Bcl-XL or Bcl-2 (52, 19), thus allowing the latter proteins to promote cell survival. least as effectively as the wild-type protein, and is more potent than wild-type BAD in inducing cytochrome c release. Phosphorylation of BAD correlates with its ability to interact with 14-3-3 beta, an association necessary for sequestration of BAD in the cytoplasm WT, mutated, and truncated forms of BAD all induced the release of cytochrome c from isolated mitochondria" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.