Matches in Nanopublications for { ?s ?p "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ?g. }
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- NP444347.RAC9j4STJ32qqiTT1mRFzd1vaqhFNSmH419k3VVw-Gd5E130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP444347.RAC9j4STJ32qqiTT1mRFzd1vaqhFNSmH419k3VVw-Gd5E130_provenance.
- NP450000.RACqEAZkuqY12hzLHC__TDxbkXB1vQTQh-t-ZmGw61c_U130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP450000.RACqEAZkuqY12hzLHC__TDxbkXB1vQTQh-t-ZmGw61c_U130_provenance.
- assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.
- NP367462.RACGxwoMwEjb0iT4JPyEDzqWiIawm2QY5RGwQYMUmm9JQ130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP367462.RACGxwoMwEjb0iT4JPyEDzqWiIawm2QY5RGwQYMUmm9JQ130_provenance.
- NP532195.RAPR0sY42Si0zTWXbUu9JFbRlQUz88PCsAaZm0sE1uBzw130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP532195.RAPR0sY42Si0zTWXbUu9JFbRlQUz88PCsAaZm0sE1uBzw130_provenance.
- NP557144.RAIfV7XoDMV94w1DpfpGxme7FFr_WPK7Pwl8VGwN2IpeE130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP557144.RAIfV7XoDMV94w1DpfpGxme7FFr_WPK7Pwl8VGwN2IpeE130_provenance.
- assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.
- NP1364915.RA6SsZfumuX9IVLIiFr8GuZzryfRE0PtrYdYeu8hNEKRc130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1364915.RA6SsZfumuX9IVLIiFr8GuZzryfRE0PtrYdYeu8hNEKRc130_provenance.
- NP251636.RALCFKUe6J7fNF4RmvuSXLIkgE46G2u4X-Una5_Ruq2i0130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP251636.RALCFKUe6J7fNF4RmvuSXLIkgE46G2u4X-Una5_Ruq2i0130_provenance.
- assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.
- NP731326.RAheSPh1F6WSDAhaY7OukHQQCqxgiDjSC5S4fAoFB7Ric130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP731326.RAheSPh1F6WSDAhaY7OukHQQCqxgiDjSC5S4fAoFB7Ric130_provenance.
- NP1364914.RAoCA_BCPz6gYWuEE_TZk5wJtkZ9wQ0D4N1C5PlUNHUQg130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1364914.RAoCA_BCPz6gYWuEE_TZk5wJtkZ9wQ0D4N1C5PlUNHUQg130_provenance.
- NP1364916.RAm9KW5mfZyjNBLlHFSgokLD_YT_W7_IdixO_qTy1da1k130_assertion description "[We conclude: (i) the mitogenic signaling pathway(s) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression; (ii) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriatic lesions; and (iii) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1364916.RAm9KW5mfZyjNBLlHFSgokLD_YT_W7_IdixO_qTy1da1k130_provenance.