Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Not Available" provenance.
- _3 value "Not Available" provenance.
- _5 value "Not Available" provenance.
- _4 value "Progesterone modulates the mammary epithelial cell cycle both by inducing the synthesis of cyclinE and CDC25A phosphatase and by triggering the degradation of p27Kip1" provenance.
- _4 value "TGFbeta is suppressive of lactation" provenance.
- _7 value "Entrez Gene summary: Human: EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF." provenance.
- _5 value "ROCK1 is a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. ROCK, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity." provenance.
- _5 value "% Entrez Gene summary: Human: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed." provenance.
- _5 value "cain/cabin 1 was found to regulate the transcription factor MEF2, itself regulated via calcineurin-dependent pathways, by binding to MEF2 and sequestering it in an inactive state" provenance.
- _5 value "Not Available" provenance.
- _5 value "Not Available" provenance.
- _4 value "Not Available" provenance.
- _5 value "Not Available" provenance.
- _6 value "For the atypical PKC isoforms, there is no phosphorylation in the hydrophobic region, which has a glutamic acid residue in place of the serine or threonine residue found in other PKC isoforms. The enzyme PDK1 or perhaps a close relative is responsible for PKC activation [Thr410/403) (PKCz,l)]" provenance.
- _5 value "E2F up-regulates expression of genes involved in DNA replication, DNA repair and mitosis We use DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data demonstrate that E2F up-regulates the expression of tens of genes not previously described as E2F target genes. Many of these novel E2F-regulated genes code for components of the DNA replication machinery. Among them are the genes coding for replication protein A (RPA). RPA is the most abundant ssDNA binding protein in eukaryotic cells and it plays an essential role in DNA replication. It is a heterotrimer composed of 70kDa (RPA1), 32kDa (RPA2) and 14kDa (RPA 3) subunits and our data show that expression of the genes, coding for these three subunits, is up-regulated by E2F. The regulation of the RPA2 gene was studied in greater detail and we show that it is directly regulated by E2F via E2F-binding sites in its promoter." provenance.
- _5 value "E2F up-regulates expression of genes involved in DNA replication, DNA repair and mitosis We use DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data demonstrate that E2F up-regulates the expression of tens of genes not previously described as E2F target genes. Many of these novel E2F-regulated genes code for components of the DNA replication machinery. Among them are the genes coding for replication protein A (RPA). RPA is the most abundant ssDNA binding protein in eukaryotic cells and it plays an essential role in DNA replication. It is a heterotrimer composed of 70kDa (RPA1), 32kDa (RPA2) and 14kDa (RPA 3) subunits and our data show that expression of the genes, coding for these three subunits, is up-regulated by E2F. The regulation of the RPA2 gene was studied in greater detail and we show that it is directly regulated by E2F via E2F-binding sites in its promoter." provenance.
- _5 value "Other novel E2F-regulated genes, identified using the DNA microarray analysis, are involved in mitosis and DNA repair. The identification of mitotic genes, including the kinases Bub1b and cdc2, as E2F-regulated genes indicates that E2F affects cell cycle progression both at the S-phase and during mitosis. The molecular mechanism(s) of E2F-dependent regulation of mitotic genes is currently being studied. The identification of DNA repair genes, including MSH2, MSH6 and BRCA1, as E2F-regulated genes raises the possibility that E2F plays a role in the response to DNA damage. This notion is supported by recent reports demonstrating that various DNA damaging agents induce an increase in E2F-1 protein level." provenance.
- _4 value "focal adhesion protein/steroid receptor co-activator; binds to hsp27 and inhibits the ability of hsp27 to provide protection against heat shock" provenance.
- _6 value "focal adhesion protein/steroid receptor co-activator; binds to hsp27 and inhibits the ability of hsp27 to provide protection against heat shock" provenance.
- _7 value "Entrez Gene summary: Rat: SUMMARY: activates RhoA, Rac1, and Cdc42 GTPases, plays a role in regulation of calcium ion dependent exocytosis, may regulate actin filament reorganization [RGD]" provenance.
- _5 value "Entrez Gene summary: Rat: SUMMARY: enzyme involved in the oxidative deamination of biogenic and xenobiotic amines [RGD] % ... Human: This gene encodes monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the mitochondrial outer membrane. The gene is adjacent to a related gene on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. OMIM summary: (summary is not available from this source)" provenance.
- _4 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _6 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _5 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _8 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _6 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _6 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _6 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _5 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _7 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _7 value "In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways." provenance.
- _6 value "LARG=ARHGEF12 cleaved proteins will be added to basics file" provenance.
- _7 value "S1P3=EDG3 S1P2=EDG5" provenance.
- _6 value "The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a welldefined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML)." provenance.
- _6 value "VEGFR-1 and VEGFR-2 mRNA was identified in a number of breast cancer cell lines including T-47D, MCF7, MDA-MB-453, and MDA-MB-231, and these cancer cells were shown to respond to VEGF.85,86 VEGF stimulation increased the invasiveness of T-47D cells in the presence of fibronectin.85 ERK-1 and -2 were activated in response to VEGF in T-47D cells; PI3-K and its downstream target Akt were also activated. Since T-47D cells secrete VEGF87 it is likely that an autocrine VEGF loop exists within these cells. PI3-K activation has often been implicated in cellular invasion88 and may be the signalling mechanism in T-47D cells that mediates VEGF-induced cell invasion." provenance.
- _6 value "Human serum was fractionated over an IGFBP3 affinity column, and a 70-kD protein was eluted, sequenced, and identified (through database searching and Western immunoblot) as human TF. Biosensor interaction analysis confirmed that this interaction is specific and sensitive, with a high association rate similar to that of IGF1 (147440), and suggested that binding occurs in the vicinity of the IGFBP3 nuclear localization site. TF treatment blocked IGFBP3-induced cell proliferation in bladder smooth muscle cells and IGFBP3-induced apoptosis in prostate cancer cells." provenance.
- _6 value "Human serum was fractionated over an IGFBP3 affinity column, and a 70-kD protein was eluted, sequenced, and identified (through database searching and Western immunoblot) as human TF. Biosensor interaction analysis confirmed that this interaction is specific and sensitive, with a high association rate similar to that of IGF1 (147440), and suggested that binding occurs in the vicinity of the IGFBP3 nuclear localization site. TF treatment blocked IGFBP3-induced cell proliferation in bladder smooth muscle cells and IGFBP3-induced apoptosis in prostate cancer cells." provenance.
- _3 value "LCAT consumes unesterified cholesterol and phospholipids to produce insoluble cholesteryl ester this is retained in the HDL core, while the water-soluble lysophosphatidylcholine formed at the same time is transferred away to albumin LCAT maintains concentration gradients of cholesterol and phosphatidylcholine between cells and lipoprotein surfaces and the growing HDL particle" provenance.
- _4 value "VLDL particles contain apoB100 and apoCs with or without apoE IDLs contain apoB100 and apoE but not apoCs LDLs contain only apoB100" provenance.
- _4 value "VLDL particles contain apoB100 and apoCs with or without apoE IDLs contain apoB100 and apoE but not apoCs LDLs contain only apoB100" provenance.
- _3 value "VLDLs secreted from the liver include a single molecule of full-length apoB100 the triacylglycerol-rich core of VLDLs contains significant levels of hepatic cholesteryl esters the incorporation of cholesteryl esters into VLDLs is necessary for their successful secretion into the perfusate the phospholipid moiety of newly synthesized VLDL is enriched in phosphatidylethanolamine newly synthesized plasma VLDLs contain apoC apoproteins but little apoE enrichment of VLDL with apoE and additional apoCs takes place in the plasma compartment" provenance.
- _4 value "absence of Abca1 results in almost complete absence of HDL and dramatic cellular cholesterol accumulation, particularly in the lungs" provenance.
- _4 value "absence of Pltp had reduced HDL levels" provenance.
- _7 value "apoa1 is likely to play the predominant role in transporting peripheral cell cholesterol through the plasma compartment to the liver apoa1 gene transcription rates are not highly regulated, compared to those of ABCA1 and other catalytic factors of the HDL cycle Sp1, a transcription factor, plays a major role in regulating apoa1 transcription rates PPARs regulate phospholipid efflux to apoa1" provenance.
- _4 value "in ABCA1 deficiency, the HDL present is all in the form of prebeta-HDL" provenance.
- _4 value "most alpha HDL particles, unlike prebeta and discoidal-HDL, include A2 as well as apoa1 evidence recently obtained suggests that these are a product of the fusion of apoA1-only and apoA2-only HDL particles this fusion could be mediated locally by the lysophosphatidylcholine formed in the LCAT reaction apoa2 has been considered an inhibitor of the LCAT reaction, and thus indirectly, of reverse cholesterol transport" provenance.
- _4 value "note, PSOAT reaction is [Phosphatidylcholine + Sterol <=> 1-Acylglycerophosphocholine + Steryl ester] LCAT can also hydrolyze short-chain lipid esters this reaction is independent of the presence of apoa1, consistent with the view that the apoprotein may be needed to align the enzyme and its substrates at a phospholipid-water interface in LCAT deficiency only lipid-poor and discoidal HDL particles are present" provenance.
- _4 value "note, THDF reaction is [Phosphatidylcholine + Sterol <=> 1-Acylglycerophosphocholine + Steryl ester]" provenance.
- _5 value "KEGG pathway: Toll-Like Receptor Signalling Pathway" provenance.
- _5 value "KEGG pathway: Toll-Like Receptor Signalling Pathway" provenance.
- _5 value "KEGG pathway: Toll-Like Receptor Signalling Pathway" provenance.
- _4 value "Second, the chemokines direct the migration of the leukocyte along a gradient of the chemokine that increases in concentration toward the site of infection." provenance.
- _8 value "Strong adhesion between leukocytes and endothelial cells is promoted by the induction of ICAM-1 on inflamed endothelium and the activation of a conformational change in LFA-1 and Mac-1 in response to chemokines." provenance.
- _4 value "The activation of endothelium is driven by interactions with macrophage cytokines, particularly TNF-a, which induces rapid externalization of granules in the endothelial cells called WeibelPalade bodies. These granules contain preformed P-selectin, which is thus expressed within minutes on the surface of local endothelial cells following production of TNF-a by macrophages." provenance.
- _7 value "Not Available" provenance.
- _7 value "Not Available" provenance.
- _5 value "Table 2 Transcription factors shown to have functional interaction with the cyp7a gene promotor" provenance.
- _5 value "Table 2 Transcription factors shown to have functional interaction with the cyp7a gene promotor" provenance.
- _6 value "Insulin-induced SREBP-1c expression and activity results in downregulation of PEPCK gene expression and upregulation of GK gene transcription (40-42), resulting in a decreased glucose production and an increased glucose uptake." provenance.
- _5 value "Entrez Gene summary: Rat: SUMMARY: major neurotransmitter-degrading enzyme in the CNS; degrades biogenic monoamines in the brain [RGD] Human: The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. OMIM summary: (summary is not available from this source)" provenance.
- _5 value "Entrez Gene summary: Rat: SUMMARY: major neurotransmitter-degrading enzyme in the CNS; degrades biogenic monoamines in the brain [RGD] Human: The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. OMIM summary: (summary is not available from this source)" provenance.
- _6 value "Oxidation of arachidonic acid to 5-HpETE. 5-lipoxygenase (5-LO) catalyzes the formation of leukotriene A4 (LTA4) from arachidonic acid (AA) in a two-step process. First, AA is oxidized to form 5-hydroperoxyeicosatetranoic acid (5-HpETE)." provenance.
- _6 value "Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, {600664}, or IKBKB, {603258}) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex." provenance.
- _4 value "HEPATOCYTE GROWTH FACTOR HGF is a cytokine with various different cellular functions. Specific to skeletal muscle hypertrophy, HGF activates satellite cells and may be responsible for causing satellite cells to migrate to the injured area (2)." provenance.
- _6 value "The sentence (Jubilant) Abeta(25-35) fibrils induced activation of Lyn, Syk, Pyk2 and focal adhesion kinase. is translated to Activation of PTK2 (Homo sapiens) Protein -> PTK2 (Homo sapiens) Protein phosphorylated at ? by APP (Homo sapiens) Protein The following edits have been made already none Links Doc Sourcerer for 11160388 APP (Homo sapiens) Protein PTK2 (Homo sapiens) Protein -> PTK2 (Homo sapiens) Protein phosphorylated at ?" provenance.
- _5 value "The sentence (Jubilant) TGFB induces phosphorylation of SMAD2 is inhibited by SB-431542 , an inhibitor of ALK4, ALK5 and ALK7. is translated to Complex of ACVR1B (Homo sapiens) Protein and TGFB1 (Homo sapiens) Protein The following edits have been made already none Links Doc Sourcerer for 12065756 ACVR1B (Homo sapiens) Protein TGFB1 (Homo sapiens) Protein" provenance.
- _4 value "The sentence (Jubilant) The inhibition of T47D cell proliferation induced by IL6 and OSM requires STAT3 activity. is translated to Activation of STAT3 (Homo sapiens) Protein by OSM (Homo sapiens) Protein The following edits have been made already none Links Doc Sourcerer for 11196191 STAT3 (Homo sapiens) Protein OSM (Homo sapiens) Protein" provenance.
- _6 value "The sentence (ResnetDB) Moreover, treatment of wild-type cells with tyrphostin AG1007, which inhibits both pp60(c-src) and FAK activity, induced accumulation of tensin in peripheral focal adhesions. is translated to Activation of TNS (Homo sapiens) Gene Expression by PTK2 (Homo sapiens) Protein The following edits have been made already none Links Doc Sourcerer for 11493667 TNS (Homo sapiens) Gene Expression PTK2 (Homo sapiens) Protein" provenance.
- _6 value "The sentence (ResnetDB) Moreover, treatment of wild-type cells with tyrphostin AG1007, which inhibits both pp60(c-src) and FAK activity, induced accumulation of tensin in peripheral focal adhesions. is translated to Activation of TNS (Homo sapiens) Gene Expression by PTK2 (Homo sapiens) Protein The following edits have been made already none Links Doc Sourcerer for 11493667 TNS (Homo sapiens) Gene Expression PTK2 (Homo sapiens) Protein" provenance.
- _5 value "Not Available" provenance.
- _5 value "Not Available" provenance.
- _5 value "Not Available" provenance.
- _6 value "Not Available" provenance.
- _7 value "Not Available" provenance.
- _6 value "Not Available" provenance.
- _5 value "this effect is mediated through E2 via the phosphorylation of extracellular-regulated kinase 1 and 2 (ERK1/2), prominent members of the mitogen-activated protein kinase (MAPK) pathway. Furthermore, we show that the activation of MAPK-signaling pathway and the enhancement of the sAPP release is independent of ERs" provenance.
- _5 value "this effect is mediated through E2 via the phosphorylation of extracellular-regulated kinase 1 and 2 (ERK1/2), prominent members of the mitogen-activated protein kinase (MAPK) pathway. Furthermore, we show that the activation of MAPK-signaling pathway and the enhancement of the sAPP release is independent of ERs" provenance.
- _6 value "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one. 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol and NAD+ react to form 4-methylcholesta-8(9),24-dien-3-one, CO2, and NADH + H+. This reaction occurs in the endoplasmic reticulum, catalyzed by NSDHL (Caldas and Herman 2003). Defects in this enzyme are associated with CHILD syndrome (Congenital Hemidysplasia with Ichthyosiform nevus and Limb Defects) (Konig et al. 2000), but cholesterol biosynthesis in cells and tissues from affected individuals has not been characterized. Instead, the mechanism and stoichiometry of the reaction are inferred from biochemical studies of partially purified rat enzyme (Rahimtula and Gaylor 1972)." provenance.
- _3 value "Diabetes is on the rise Our population is older Hyperinsulinemia Stimulates fat storage Increases appetite Increase in vascular smooth muscle proliferation" provenance.
- _7 value "A few studies evaluating mixed or NOS DCIS found a 100% incidence of MYC protein expression by IHC,and an 11% rate of myc amplification MYC proteins form heterodimeric complexes with basic helix-loop-helix-leucine zipper transcription factors whose activity is regulated by a number of positive (MAX) and negative (MAD, MXI1) regulators." provenance.
- _4 value "VEGF has been shown to promote endothelial cell survival by inhibiting apoptosis pathways, upregulating antiapoptotic proteins such as BCL2 and survivin, and activating proteins such as focal adhesion kinase that maintain endothelial cell survival despite apoptotic stimuli" provenance.
- _4 value "VEGF has been shown to promote endothelial cell survival by inhibiting apoptosis pathways, upregulating antiapoptotic proteins such as BCL2 and survivin, and activating proteins such as focal adhesion kinase that maintain endothelial cell survival despite apoptotic stimuli" provenance.
- _6 value "There was a concomitant glucose-dependent onset of expression of Protein Kinase C (PKC)-isoforms PKC-delta (2.5 +/- 0.3-fold), PKC-epsilon (2 +/- 0.2-fold) and PKC-zeta (1.8 +/- 0.2-fold), which reached a maximum after 12 h and was still visible during long-term culture. Induction of fibronectin expression was also obtained using the PKC-activating phorbolester" provenance.
- _6 value "There was a concomitant glucose-dependent onset of expression of Protein Kinase C (PKC)-isoforms PKC-delta (2.5 +/- 0.3-fold), PKC-epsilon (2 +/- 0.2-fold) and PKC-zeta (1.8 +/- 0.2-fold), which reached a maximum after 12 h and was still visible during long-term culture. Induction of fibronectin expression was also obtained using the PKC-activating phorbolester" provenance.
- _8 value "There was a concomitant glucose-dependent onset of expression of Protein Kinase C (PKC)-isoforms PKC-delta (2.5 +/- 0.3-fold), PKC-epsilon (2 +/- 0.2-fold) and PKC-zeta (1.8 +/- 0.2-fold), which reached a maximum after 12 h and was still visible during long-term culture. Induction of fibronectin expression was also obtained using the PKC-activating phorbolester" provenance.
- _8 value "There was a concomitant glucose-dependent onset of expression of Protein Kinase C (PKC)-isoforms PKC-delta (2.5 +/- 0.3-fold), PKC-epsilon (2 +/- 0.2-fold) and PKC-zeta (1.8 +/- 0.2-fold), which reached a maximum after 12 h and was still visible during long-term culture. Induction of fibronectin expression was also obtained using the PKC-activating phorbolester" provenance.
- _5 value "There was a concomitant glucose-dependent onset of expression of Protein Kinase C (PKC)-isoforms PKC-delta (2.5 +/- 0.3-fold), PKC-epsilon (2 +/- 0.2-fold) and PKC-zeta (1.8 +/- 0.2-fold), which reached a maximum after 12 h and was still visible during long-term culture. Induction of fibronectin expression was also obtained using the PKC-activating phorbolester" provenance.
- _5 value "There was a concomitant glucose-dependent onset of expression of Protein Kinase C (PKC)-isoforms PKC-delta (2.5 +/- 0.3-fold), PKC-epsilon (2 +/- 0.2-fold) and PKC-zeta (1.8 +/- 0.2-fold), which reached a maximum after 12 h and was still visible during long-term culture. Induction of fibronectin expression was also obtained using the PKC-activating phorbolester" provenance.
- _7 value "There was a concomitant glucose-dependent onset of expression of Protein Kinase C (PKC)-isoforms PKC-delta (2.5 +/- 0.3-fold), PKC-epsilon (2 +/- 0.2-fold) and PKC-zeta (1.8 +/- 0.2-fold), which reached a maximum after 12 h and was still visible during long-term culture. Induction of fibronectin expression was also obtained using the PKC-activating phorbolester" provenance.
- _5 value "Entrez Gene summary: Human: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1." provenance.
- _6 value "Not Available" provenance.
- _4 value "Not Available" provenance.
- _4 value "Not Available" provenance.
- _4 value "Not Available" provenance.
- _4 value "Not Available" provenance.
- _4 value "Not Available" provenance.
- _5 value "Not Available" provenance.
- _5 value "Not Available" provenance.
- _6 value "Not Available" provenance.
- _3 value "Not Available" provenance.