Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _5 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _5 value "Together, the results suggest that 14-3-3 binds both PKC-zeta (at phospho-Ser-186) and Raf-1 in a ternary complex. Phosphorylation of 14-3-3beta by PKC-zeta negatively regulated their physical association. 14-3-3beta with its putative PKC-zeta phosphorylation sites mutated enhanced co-precipitation between PKC-zeta and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-zeta weakens the complex in vivo. We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-zeta." provenance.
- _7 value "complex formation between PKC-zeta and Raf-1 is mediated strongly by the 14-3-3beta and -theta" provenance.
- _5 value "protein kinase C-zeta (PKC-zeta) can phosphorylate and activate Raf-1 in a signalling complex" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "IL-18 was subsequently shown to induce eotaxin production from bronchial epithelial cells and isolated macrophages in in vitro assays" provenance.
- _3 value "3) sHSPs whose mRNAs are induced by heat shock are alphaB-crystallin and HSP27." provenance.
- _3 value "The expressions of MKBP/HSPB2 and HSPB3 are induced during muscle differentiation under the control of MyoD, suggesting that the sHSP oligomer comprising MKBP/HSPB2 and HSPB3 represents an additional system closely related to muscle function." provenance.
- _3 value "BNIP3 expressed in yeast and mammalian cells interacts with survival promoting proteins Bcl-2, Bcl-X(L), and CED-9." provenance.
- _5 value "Binding of PIAS1 to human AR DNA+ligand binding domains was androgen dependent in the yeast liquid beta-galactosidase assay. PIAS1 binding to full-length human AR in a reversed yeast two hybrid system was also androgen dependent." provenance.
- _4 value "Effect of NGF on the Expression of PSA Continuous exposure of LNCaP cells to NGF markedly enhanced the expression of PSA, a typical marker of cellular differentiation in prostatic epithelial cells." provenance.
- _3 value "Exposition of monocyte-derived macrophages isolated from healthy donors to a high glucose environment led to an increase in PPARalpha and PPARbeta mRNA expression. In contrast, this treatment significantly decreased human macrophage PPARgamma mRNA expression." provenance.
- _3 value "Exposition of monocyte-derived macrophages isolated from healthy donors to a high glucose environment led to an increase in PPARalpha and PPARbeta mRNA expression. In contrast, this treatment significantly decreased human macrophage PPARgamma mRNA expression." provenance.
- _4 value "The normal actions of HNF-1 include enhancing the transcription of apo B 23 24 25 and suppressing the transcription of apo AI. 27 Thus, in subjects with type 2 diabetes, the lower plasma total and LDL cholesterol and apo B levels would also be consistent with transactivational loss of function of the HNF1A S319 product." provenance.
- _4 value "The mechanism for the cell cycle downregulation appeared to be a transcriptional downregulation of E2F-1, a transcription factor that regulates genes required for cell cycle progression beyond the G1/S interphase." provenance.
- _5 value "The mechanism for the cell cycle downregulation appeared to be a transcriptional downregulation of E2F-1, a transcription factor that regulates genes required for cell cycle progression beyond the G1/S interphase." provenance.
- _4 value "p90RSK activation by H(2)O(2) was significantly reduced in fibroblasts derived from transgenic mice deficient in Fyn, but not c-Src. " provenance.
- _4 value "Activation of the Adss1 gene involves the calcineurin-mediated dephosphorylation of NFAT3, allowing its translocation to the nucleus, where it can directly participate in Adss1 gene activation." provenance.
- _5 value "overexpression of full-length PICOT (but not its N- or C-terminal fragments) in T cells inhibited the activation of c-Jun N-terminal kinase and the transcription factors AP-1 or NF-kappaB." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Mouse bone marrow cells treated with 20 ng/ml of TNF-alpha for 1 hour activated NFkB. Nuclear extracts were prepared and analyzed by an ESMA with an NF-kB binding oligonucleotide probe." provenance.
- _3 value "As AR expression can be reduced by an increase in intracellular calcium levels" provenance.
- _3 value "Proinflammatory cytokines, including IL-1beta and tumor necrosis factor-alpha (TNF-alpha), promote cancer cell adhesion and liver metastases by up-regulating the expression of vascular cell adhesion molecule-1 (VCAM-1)" provenance.
- _4 value "Reduction in the expression levels of Math2 (dorsal -specific neuronal marker) was observed in the dorsal and medial telencephalic preplate of Ngn2 mutant at E12.5 as compared to wild-type. These results demonstrate that Ngn2 plays an important role in the upregulation of dorsal postmitotic markers leading to dorsal neuron specification." provenance.
- _4 value "Reduction in the expression levels of Nscl2 (dorsal -specific neuronal marker) was observed in the dorsal and medial telencephalic preplate of Ngn2 mutant at E12.5 as compared to wild-type. These results demonstrate that Ngn2 plays an important role in the upregulation of dorsal postmitotic markers leading to dorsal neuron specification." provenance.
- _4 value ".Although the mediator of p160ROCK signaling to the nucleus is not certain, inhibitors of c-Jun NH2-terminal kinase can block ET-1-induced cardiac hypertrophy (17). INTEGRIN SIGNALING AND SKELETAL MUSCLE HYPERTROPHY The function of integrin-mediated signaling has been extensively examined in cardiac muscle and linked to some types of cardiac hypertrophy (59)." provenance.
- _3 value "Chick and rat skeletal muscle subjected to chronic overload for as little as 24-36 h increases the protein concentration of FAK (28). FAK activity is also increased in hypertrophying chick skeletal muscle and is independent of increased FAK protein concentration (28)." provenance.
- _4 value "DOWNSTREAM OF INTEGRIN-MEDIATED SIGNALING Integrin interaction with the extracellular matrix and the subsequent formation of focal adhesion complexes can directly alter transcription (29) and translation (42)." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "in contrast to the direct recruitment of Stat4 by the IL-12 receptor, Stat4 activation by the human IFN-alpha receptor occurs through indirect recruitment by intermediates involving Stat2" provenance.
- _6 value "in contrast to the direct recruitment of Stat4 by the IL-12 receptor, Stat4 activation by the human IFN-alpha receptor occurs through indirect recruitment by intermediates involving Stat2" provenance.
- _5 value "This mutant NF-YA, which sequesters NF-YB and NF-YC into a functionally inactive heterotrimer ( 32 ), significantly reduced activation of the MDR1 promoter by UV irradiation (Fig. 3 A ), indicating a role for NF-Y in the UV response......We have previously shown that the CCAAT box-binding protein, NF-Y, mediates MDR1 activation by the histone deacetylase inhibitors, trichostatin A and sodium butyrate, through the recruitment of the co-activator, P/CAF. (9632821)--[shows direct NF-Y subunit binding --DD]" provenance.
- _3 value "In endothelial cells, the PPARgamma agonists troglitazone at 100 micromol/L and 15-deoxy-(Delta12,14)-prostaglandin J(2) (15d-PGJ2) at 20 micromol/L markedly attenuated the tumor necrosis factor-induced expression of VCAM-1 and ICAM-1." provenance.
- _3 value "Sequencing identified 4 differentially expressed genes enhanced by tracheal ligation: hepatoma-derived growth factor (HDGF), ribosomal protein S24, stathmin, and parathyroid hormone (PTH)." provenance.
- _6 value "B9 clones expressing either wild-type FGFR3 at high levels or mutant FGFR3 displayed increased phosphorylation of STAT3 and higher levels of bcl-x(L) expression than did parental B9 cells after cytokine withdrawal." provenance.
- _3 value "Recent studies have reported that estrogens in mammary tumors ( 40 ) and androgens in prostatic cell lines ( 41 ) modulate cell proliferation by up-regulating EGF receptor and IGF1R expression." provenance.
- _5 value "The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) (GDNF, neurturin, artemin, and persephin) are critical regulators of neurodevelopment and support the survival of midbrain dopaminergic and spinal motor neurons in vitro and in animal disease models making them attractive therapeutic candidates for treatment of neurodegenerative diseases. The GFLs signal through a multicomponent receptor complex comprised of a high affinity binding component (GDNF-family receptor alpha-component (GFRalpha1-GFRalpha4)) and the receptor tyrosine kinase RET." provenance.
- _5 value "Furthermore, IL-18R at least partly shares the signal transducing system with IL-1R. Thus, the IL-18-IL-18R system has a striking similarity to the IL-1-IL-1R system. From entrez gene summary of IL1R1: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses." provenance.
- _5 value "FHL2 contains a strong, autonomous transactivation function and binds specifically to the AR in vitro and in vivo. In an agonist- and AF-2-dependent manner FHL2 selectively increases the transcriptional activity of the AR, but not that of any other nuclear receptor. In addition, the transcription of the prostate-specific AR target gene probasin is coactivated by FHL2" provenance.
- _5 value "complex" provenance.
- _7 value "We report in this study that CDK9, the cyclin T associated kinase, which phosphorylates and activates RNA-Polymerase II, suppresses B-Myb autoregulation through direct interaction with the carboxyl-terminus of the B-Myb protein." provenance.
- _4 value "At the time of disease onset (day 7), a 2 to 5-fold increase in expression of CCR3 was observed. In GL3-treated mice, reduced levels of CCR3 was observed on day 6 and remained lower than in the EAE controls on day 7." provenance.
- _4 value "We demonstrate for the first time TNF-alpha dose-dependent induction of TRAF1 protein and messenger RNA (mRNA) in human H441 and A549 pulmonary adenocarcinoma cell lines, as well as in lung cells of C57BL/6J mice after intratracheal administration of TNF-alpha." provenance.
- _3 value "For the first time, we report that a single bout of exercise is sufficient to cause upregulation of GLUT-4 and glycogenin gene expression in human skeletal muscle." provenance.
- _5 value "A STAT3 peptide was efficiently phosphorylated on Ser727 in a CNTF-dependent manner by mTOR, but not by a kinase-inactive mTOR mutant or by p70 S6 kinase." provenance.
- _4 value "To confirm that the expressed FSH receptor was functional, MSC-1F cells were treated with FSH for 1 h, and the subsequent induction of the FSH-responsive c- fos mRNA was examined." provenance.
- _5 value "All the sites contained consensus sequences for the serine/threonine-proline-directed family of protein kinases, and two sites (serine 395 and threonine 1179) contained a perfect consensus sequence for the mitogen-activated protein kinase family (Erk-1 and Erk-2). % Erk-2 phosphorylated threonine 1179 and serine 1185 (and to a lesser extent, serine 395) in vitro," provenance.
- _5 value "Furthermore, Erk-2 phosphorylated threonine 1179 and serine 1185 (and to a lesser extent, serine 395) in vitro, suggesting the importance of this pathway for SRC-1 regulation." provenance.
- _2 value "In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these modified lipoproteins activate endothelial cells, which attract circulating monocytes. These monocytes enter the vessel wall, differentiate into macrophages, and subject the modified lipoproteins to endocytosis through scavenger receptor pathways. This unrestricted uptake, which is not limited by intracellular cholesterol levels, eventually leads to the formation of lipid-filled foam cells, the initial step in atherosclerosis" provenance.
- _4 value "TNF-alpha induced rapid biphasic increase in ERK1/2 phosphorylation which was detected as early as 2 minutes after addition of TNF-alpha and reached a maximum after 15 mins." provenance.
- _4 value "jubilant" provenance.
- _6 value "The mammalian Ste20 kinase Nck-interacting kinase (NIK) specifically activates the c-Jun amino-terminal kinase (JNK) mitogen-activated protein kinase module." provenance.
- _5 value "activated calcineurin stimulates transcriptional activity of MEF2 transcription factors (12), expressed in T cells and muscle" provenance.
- _5 value "Although both cGK-Ialpha and -Ibeta, but not cAMP-dependent protein kinase, phosphorylated GKAP42 in vitro, GKAP42 was a good substrate only for cGK-Ialpha in intact cells" provenance.
- _5 value "Finally, we demonstrated that the kinase-deficient mutant of cGK-Ialpha stably associates with GKAP42 and that binding of cGMP to cGK-Ialpha facilitates their release from GKAP42." provenance.
- _3 value "Moreover, the expression of Drg-1 is controlled by several known cell differentiation reagents, such as ligands of peroxisome proliferator-activated receptor gamma (troglitazone and BRL46593) and of retinoid X receptor (LG268), and histone deacetylase inhibitors (trichostatin A, suberoylanilide hydroxamic acid, and tributyrin)." provenance.
- _4 value "COX-2 is inducible by oncogenes ras and scr, interleukin-1, hypoxia, benzo[a]pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha." provenance.
- _5 value "COX-2 is inducible by oncogenes ras and scr, interleukin-1, hypoxia, benzo[a]pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha." provenance.
- _3 value "COX-2 synthesizes prostaglandin E2 (PGE2) which stimulates bcl-2 and inhibits apoptosis, and induces interleukin-6 (IL-6) which enhances haptoglobin synthesis. PGE2 is associated with tumor metastases, IL-6 with cancer cell invasion, and haptoglobin with implantation and angiogenesis" provenance.
- _4 value "COX-2 synthesizes prostaglandin E2 (PGE2) which stimulates bcl-2 and inhibits apoptosis, and induces interleukin-6 (IL-6) which enhances haptoglobin synthesis. PGE2 is associated with tumor metastases, IL-6 with cancer cell invasion, and haptoglobin with implantation and angiogenesis" provenance.
- _4 value "Ligation of alpha 5 beta 1 using activating mAb JBS5 (which acts as agonist similar to FN N-terminal fragment) up-regulates the inflammatory mediators such as NO and PGE2 as well as the cytokines, IL-6 and IL-8. Furthermore, up-regulation of these proinflammatory mediators by alpha 5 beta1 integrin ligation is mediated via induction and autocrine production of IL-1 beta, because type II soluble IL-1 decoy receptor inhibits their production." provenance.
- _5 value "Ligation of alpha 5 beta 1 using activating mAb JBS5 (which acts as agonist similar to FN N-terminal fragment) up-regulates the inflammatory mediators such as NO and PGE2 as well as the cytokines, IL-6 and IL-8. Furthermore, up-regulation of these proinflammatory mediators by alpha 5 beta1 integrin ligation is mediated via induction and autocrine production of IL-1 beta, because type II soluble IL-1 decoy receptor inhibits their production." provenance.
- _7 value "Ligation of alpha 5 beta 1 using activating mAb JBS5 (which acts as agonist similar to FN N-terminal fragment) up-regulates the inflammatory mediators such as NO and PGE2 as well as the cytokines, IL-6 and IL-8. Furthermore, up-regulation of these proinflammatory mediators by alpha 5 beta1 integrin ligation is mediated via induction and autocrine production of IL-1 beta, because type II soluble IL-1 decoy receptor inhibits their production." provenance.
- _4 value "Treatment with IL-18 increased the production of IFNG, IL-4 and IL-5." provenance.
- _4 value "Rsk1 directly phosphorylated the pro-apoptotic protein Bad at the serine %residues that, when phosphorylated, abrogate Bad's pro-apoptotic function." provenance.
- _3 value "both Hoxa4 and Hoxa5 are upregulated when cultured in the presence of all-trans retinoic acid." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "# sentences for pubmedID=10681561: # Ariadne: Epiregulin up-regulated the mRNA levels of heparin-binding EGF-like growth factor (HB-EGF ), amphiregulin, and TGF-alpha. [Regulation]" provenance.
- _4 value "The rat CB2 receptor also demonstrated coupling to G-proteins and to adenylate cyclase by its activity in two different functional assays, stimulation of GTPgamma S binding and inhibition of forskolin-stimulated cAMP accumulation." provenance.
- _4 value "The rat CB2 receptor also demonstrated coupling to G-proteins and to adenylate cyclase by its activity in two different functional assays, stimulation of GTPgamma S binding and inhibition of forskolin-stimulated cAMP accumulation." provenance.
- _4 value "Finally, IL-13 inhibited IL-1beta-induced matrix metalloproteinase (MMP)-1 and MMP-3 production and enhanced tissue inhibitor of metalloproteinase (TIMP)-1 generation from NF; although similar effects were observed with IL-4, TGF-beta(1) transiently enhanced MMP-1 and MMP-3 generation without effecting TIMP-1." provenance.
- _4 value "For instance, interleukin-2 can down-regulate BSAP expression, thereby relieving BSAP repression of the Ig J-chain gene ( 55 )." provenance.
- _5 value "in Chat-overexpressed cells, the activity of c-Jun N-terminal kinase was up-regulated" provenance.
- _4 value "treatment of cells with epidermal growth factor or nerve growth factor increased the phosphorylation level of Chat, phosphorylation of Chat by MAP kinase" provenance.
- _4 value "Actinomycin D treatment inhibited both Ang II- and phorbol-12-myristate-13-acetate-stimulated RGS2 up-regulation" provenance.
- _4 value "Phorbol-12-myristate-13-acetate, a PKC activator, robustly increased RGS2. This signal was attenuated by the PKC inhibitor GF 109203X (50 +/- 4%) and by phorbol-12, 13-dibutyrate-mediated down-regulation of PKC" provenance.
- _3 value "Phorbol-12-myristate-13-acetate, a PKC activator, robustly increased RGS2. This signal was attenuated by the PKC inhibitor GF 109203X (50 +/- 4%) and by phorbol-12, 13-dibutyrate-mediated down-regulation of PKC" provenance.
- _6 value "Protein tyrosine phosphatase alpha (PTPalpha) is believed to dephosphorylate physiologically the Src proto-oncogene at phosphotyrosine (pTyr)527, a critical negative-regulatory residue. It thereby activates Src" provenance.
- _4 value "# Ariadne: Furthermore, Ang II stimulated the expression of immediate-early genes, including c- fos , c- jun , jun B , Egr-1 , and c- myc (Sadoshima and Izumo, 1993 )" provenance.
- _4 value "# Ariadne: Furthermore, Ang II stimulated the expression of immediate-early genes, including c- fos , c- jun , jun B , Egr-1 , and c- myc (Sadoshima and Izumo, 1993 )" provenance.
- _4 value "Activation of all MAP kinases depends on dual phosphorylation of specific tyrosine and threonine residues, which are located on the TXY motif in the linker loop 12 (L12) region of the kinase subdomain VIII [373]. These reactions are catalyzed by dual-specificity threonine and tyrosine kinases belonging to the MKK family (Fig. 1). Specificity is determined by the sequence of the TXY motif as well as by the length of the L12 loop. A relatively large number of intracellular proteins with diverse functions and different subcellular localization [374-378] have been identified as targets for phosphorylation by the MAP kinases. Members of the ERK, JNK (Fig. 1), and p38 MAP kinase subfamilies phosphorylate the COOH-terminal transcriptional activation domain of Elk-1 and SAP-1 [379-385], which then associates with other nuclear proteins to form TCF. The TCF proteins belong to a subgroup of the Etsdomain family of transcription factors, which includes Elk-1, SAP-1 [386,387], and NET-1/ERP/SAP-2 [388]. TCF proteins are incapable of autonomous binding to the promoter region and thus require interaction with other transcription factors such as the SRF [389,390]. Transcriptional activation of many genes is mediated by binding a multiprotein complex comprising an SRF homodimer and a member of the TCF family [391,392] to the SRE in their promoter region. The SRE cis-acting element (Fig. 1) was initially identified as the region in the promoter of c-fos and other immediate-early response genes responsible for their transcriptional induction on serum stimulation [393,394]. SRE also mediates increased gene expression in cells treated with specific growth factors, phorbol esters, and cytokines or subjected to environmental stress [381]. Two other critical promoter regions are the sis-inducible element and the CRE. Binding to both of these elements is dependent on the presence of an intact SRE [395-399]. Although exceptions are known, in general, growth factors, phorbol esters, and antioxidant compounds induce the activation of the ERK isoforms p44ERK/ERK1 and p42ERK/ERK2, and exposure of cells to UV and various forms of environmental stress activates the JNK, p38, and big MAP kinase subfamilies [54,132,371,377]. Not surprisingly, the effects of oxidants and reductants on many 'redox-sensitive' genes are mediated through effects on the MAP kinases. For example, mitogen and stress-activated protein kinase (MSK-1) is activated by oxidative stress; however, the effect is mediated by the p38 and ERK pathways [242]. Similarly, UV irradiation of mouse cells stimulates phosphorylation of p53 apparently via the JNK-1 pathway [267]. The c-fos gene is one of the best-studied early response genes; it is stimulated by a variety of oxidizing and reducing treatments [27, 53,54,381]. Because many of the pathways leading to the induction of c-fos are known, an analysis of its induction by reductants and oxidants has been useful in elucidating the mechanisms by which perturbation of redox state alters gene expression (Fig. 1). Choi and Moore [78] demonstrated that an isolated c-fos SRE site responds to treatment with the phenolic antioxidants butylated hydroxytoluene (BHT) and BHA. Because phosphorylation of p62tcf (Elk-1) [400,401] is mediated by MAP kinase [390] and is required for activation of the SRE, these observations also implicate MAP kinases in mediating the effects of reducing agents on c-fos transcription (Table 1). NF-kB The NF-k-B/Rel family of transcription factors is involved in the regulation of numerous genes, including acute phase proteins, cell surface receptors, and cytokines; they also regulate certain viral genes [402-405]. The activation of antioxidant responses is mediated partially through NF- kB, which has been found to be one factor involved in the transcriptional regulation of both SOD-2 [406,407] and g-glutamylcysteine synthetase [252]." provenance.
- _6 value "Once activated, Raf-1 phosphorylates serines in the catalytic sites of MKK/MEK [345,367]. MKK1/MEK1 and MKK2/MEK2 activate members of the MAP kinase family (ERK-1/ERK-2)," provenance.
- _2 value "Progesterone inhibits the proliferation of normal breast epithelial cells in vivo, as well as breast cancer cells in vitro." provenance.
- _3 value "tBH treatment of hRPE cells resulted in increased expression of FasL and Fas. Glutathione and NAC completely abrogated tBH-induced increase in FasL and Fas expression" provenance.
- _2 value "Phorbol esters, the activators of protein kinase C (PKC), induce apoptosis in androgen-sensitive LNCaP prostate cancer cells." provenance.
- _5 value "Highly purified ATM phosphorylated PHAS-I, the 32-kDa subunit of RPA, serine 15 of p53, and Chk2 in vitro." provenance.
- _4 value "The CD44 glycoprotein is expressed in multiple isoforms on a variety of cell types where it functions as a receptor for hyaluronan-mediated motility." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "The TPA-induced monocytic differentiation of U937, which also resulted in growth arrest, abruptly downregulated the expression of 3-PGDH. Removal of TPA restored cell growth through the retrodifferentiation process and subsequent expression of 3-PGDH" provenance.
- _6 value "These data suggest that MKK7 was largely responsible for JNK3 alpha 1 activation and that a single threonine phosphorylation may be all that is needed for JNK3 alpha 1 to be active" provenance.
- _3 value "Trichostatin A showed similar effects on cyclin D1 and D3. Butyrate and trichostatin A stimulated p21 expression both at the mRNA and protein levels" provenance.
- _4 value "vasopressin directly induces myocyte hypertrophic growth via the V1A receptor in neonatal rat heart cells" provenance.
- _5 value "We found that c-Met in tumor cells co-immunoprecipitates with EGFR regardless of the existence of their ligands in tumor cells, but not in normal human hepatocytes." provenance.
- _6 value "ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinase. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB." provenance.