Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAbfZnk6ZfhFSvkN8m1m_IOh7z0APQqMCA-uePIPOSo_g#_4> ?p ?o ?g. }
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- _4 wasQuotedFrom 10679109 provenance.
- _4 value "Ligation of alpha 5 beta 1 using activating mAb JBS5 (which acts as agonist similar to FN N-terminal fragment) up-regulates the inflammatory mediators such as NO and PGE2 as well as the cytokines, IL-6 and IL-8. Furthermore, up-regulation of these proinflammatory mediators by alpha 5 beta1 integrin ligation is mediated via induction and autocrine production of IL-1 beta, because type II soluble IL-1 decoy receptor inhibits their production." provenance.