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- drugbank:DB01120 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01120 label "Gliclazide [drugbank:DB01120]" assertion.
- drugbank:DB01120 seeAlso DB01120 assertion.
- drugbank:DB01120 description "Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%)." assertion.
- drugbank:DB01120 identifier "drugbank:DB01120" assertion.
- drugbank:DB01120 title "Gliclazide" assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01297 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00264_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00446_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00812_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00945_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00636_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01045_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00373_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01397 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01193 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00266_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00571_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01136 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00960_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00052_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00187_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01295 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00598_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00195_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01401 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01296 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00335_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01580 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01398 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00612_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01399 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00521_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00489_DB01120 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01203 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01359 assertion.
- drugbank:DB01120 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01120_DB01294 assertion.
- drugbank:DB01120 drugbank_vocabulary:food-interaction drugbank_resource:4f8e7d7b7a03f80525934a074d9e985b assertion.
- drugbank:DB01120 drugbank_vocabulary:x-cas cas:21187-98-4 assertion.
- drugbank:DB01120 drugbank_vocabulary:drugbank-id "APRD00460" assertion.
- drugbank:DB01120 drugbank_vocabulary:drugbank-id "DB01120" assertion.
- drugbank:DB01120 bio2rdf_vocabulary:x-identifiers.org DB01120 assertion.
- drugbank:DB01120 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01120" assertion.
- drugbank:DB01120 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01120 bio2rdf_vocabulary:identifier "DB01120" assertion.
- drugbank:DB01120 drugbank_vocabulary:x-wikipedia wikipedia:Gliclazide assertion.
- drugbank:DB01120 drugbank_vocabulary:x-pharmgkb pharmgkb:PA10892 assertion.
- drugbank:DB01120 drugbank_vocabulary:x-kegg kegg:D01599 assertion.
- drugbank:DB01120 drugbank_vocabulary:x-dpd dpd:2248453 assertion.
- drugbank:DB01120 drugbank_vocabulary:x-chebi chebi:31654 assertion.
- drugbank:DB01120 drugbank_vocabulary:x-atc atc:A10BB09 assertion.
- drugbank:DB01120 drugbank_vocabulary:x-ahfs ahfs:68:20.20 assertion.