Matches in Nanopublications for { <http://bio2rdf.org/drugbank:DB01142> ?p ?o ?g. }
- drugbank:DB01142 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01142 label "Doxepin [drugbank:DB01142]" assertion.
- drugbank:DB01142 seeAlso doxepin.htm assertion.
- drugbank:DB01142 seeAlso doxepin-capsules.html assertion.
- drugbank:DB01142 seeAlso DB01142 assertion.
- drugbank:DB01142 description "Doxepin hydrochloride is a dibenzoxepin-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation. In depressed individuals, doxepin exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as doxepin and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Doxepin has less sedative and anticholinergic effects than amitriptyline. See toxicity section below for a complete listing of side effects. Doxepin may be used to treat depression and insomnia. Unlabeled indications include chronic and neuropathic pain, and anxiety. Doxepin may also be used as a second line agent to treat idiopathic urticaria." assertion.
- drugbank:DB01142 identifier "drugbank:DB01142" assertion.
- drugbank:DB01142 title "Doxepin" assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB01624 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00539_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00843_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB01623 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00488_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB01364 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00723_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00726_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB01288 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB06708 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00610_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00388_DB01142 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00752_DB01142 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00241_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00368_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00780_DB01142 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00315_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00472_DB01142 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00604_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB06697 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01001_DB01142 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB06700 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00656_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB02546 assertion.
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- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01142_DB08919 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00615_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00285_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00246_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00908_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00679_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00397_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00342_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00501_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01045_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00193_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00427_DB01142 assertion.
- drugbank:DB01142 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00662_DB01142 assertion.
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- drugbank:DB01142 drugbank_vocabulary:x-cas cas:1668-19-5 assertion.
- drugbank:DB01142 drugbank_vocabulary:drugbank-id "APRD00398" assertion.
- drugbank:DB01142 drugbank_vocabulary:drugbank-id "DB01142" assertion.
- drugbank:DB01142 bio2rdf_vocabulary:x-identifiers.org DB01142 assertion.
- drugbank:DB01142 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01142" assertion.
- drugbank:DB01142 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01142 bio2rdf_vocabulary:identifier "DB01142" assertion.
- drugbank:DB01142 drugbank_vocabulary:x-wikipedia wikipedia:Doxepin assertion.
- drugbank:DB01142 drugbank_vocabulary:x-pharmgkb pharmgkb:PA449409 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-kegg kegg:D07875 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-kegg kegg:C06971 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-dpd dpd:1913425 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-chebi chebi:4710 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-atc atc:N06AA12 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-ahfs ahfs:84:08.00 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-ndc ndc:0378-1049-01 assertion.
- drugbank:DB01142 drugbank_vocabulary:x-iuphar iuphar:1225 assertion.