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- drugbank:DB01298 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01298 label "Sulfacytine [drugbank:DB01298]" assertion.
- drugbank:DB01298 seeAlso DB01298 assertion.
- drugbank:DB01298 description "Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Sulfacytine is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid." assertion.
- drugbank:DB01298 identifier "drugbank:DB01298" assertion.
- drugbank:DB01298 title "Sulfacytine" assertion.
- drugbank:DB01298 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00563_DB01298 assertion.
- drugbank:DB01298 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00672_DB01298 assertion.
- drugbank:DB01298 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46505483 assertion.
- drugbank:DB01298 drugbank_vocabulary:x-pubchemcompound pubchem.compound:5322 assertion.
- drugbank:DB01298 drugbank_vocabulary:x-chemspider chemspider:5131 assertion.
- drugbank:DB01298 drugbank_vocabulary:x-cas cas:17784-12-2 assertion.
- drugbank:DB01298 drugbank_vocabulary:drugbank-id "DB01298" assertion.
- drugbank:DB01298 bio2rdf_vocabulary:x-identifiers.org DB01298 assertion.
- drugbank:DB01298 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01298" assertion.
- drugbank:DB01298 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01298 bio2rdf_vocabulary:identifier "DB01298" assertion.
- drugbank:DB01298 drugbank_vocabulary:x-pharmgkb pharmgkb:PA164754808 assertion.