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- drugbank:DB01501 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01501 label "Difenoxin [drugbank:DB01501]" assertion.
- drugbank:DB01501 seeAlso motofen-drug.htm assertion.
- drugbank:DB01501 seeAlso motofen.html assertion.
- drugbank:DB01501 seeAlso DB01501 assertion.
- drugbank:DB01501 seeAlso lookup.cfm?setid=a07005a9-6f31-4cd6-9abf-334a9a882551 assertion.
- drugbank:DB01501 description "Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a brand mixture which combines atropine sulfate and difenoxin hydrochloride. It is approved by the FDA to treat acute and chronic diarrhea. Difenoxin is an active metabolite of the anti-diarrheal drug, diphenoxylate, which is also used in combination with atropine in the brand mixture Lomotil(R). It works mostly in the periphery and activates opioid receptors in the intestine rather than the central nervous system (CNS). [3] Difenoxin is also closely related to loperamide, but unlike loperamide it is still capable of crossing the blood brain barrier to produce weak sedative and analgesic effects. However, the antidiarrheal potency of difenoxin is much greater than its CNS effects, which makes it an attractive alternative to other opioids." assertion.
- drugbank:DB01501 identifier "drugbank:DB01501" assertion.
- drugbank:DB01501 title "Difenoxin" assertion.
- drugbank:DB01501 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01501_DB06274 assertion.
- drugbank:DB01501 drugbank_vocabulary:food-interaction drugbank_resource:1dc48211a60bc76fde2a3c0a019a1343 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46508854 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-pubchemcompound pubchem.compound:34328 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-chemspider chemspider:31620 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-cas cas:28782-42-5 assertion.
- drugbank:DB01501 drugbank_vocabulary:drugbank-id "DB01501" assertion.
- drugbank:DB01501 bio2rdf_vocabulary:x-identifiers.org DB01501 assertion.
- drugbank:DB01501 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01501" assertion.
- drugbank:DB01501 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01501 bio2rdf_vocabulary:identifier "DB01501" assertion.
- drugbank:DB01501 drugbank_vocabulary:x-wikipedia wikipedia:Difenoxin assertion.
- drugbank:DB01501 drugbank_vocabulary:x-kegg kegg:D03809 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-kegg kegg:C07871 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-chebi chebi:4534 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-atc atc:A07DA04 assertion.
- drugbank:DB01501 drugbank_vocabulary:x-ndc ndc:0187-0500-01 assertion.