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- drugbank:DB05464 type drugbank_vocabulary:Drug assertion.
- drugbank:DB05464 label "NOX-700 [drugbank:DB05464]" assertion.
- drugbank:DB05464 seeAlso DB05464 assertion.
- drugbank:DB05464 description "NOX-700, an new orally active dithiocarbamate-based nitric oxide (NO) blocking agent that is in development for the treatment of diabetes mellitus (type 2 diabetes). In animal studies, NOX-700 lowered serum glucose, improved glucose tolerance, and reduced the percentage of total glycated hemoglobin. Immunohistochemical studies on pancreatic tissue also showed that NOX-700 therapy effectively preserved islet structure and increased insulin immunoreactivity. It has since been found that oxidative signaling of the redox-sensitive transcription factor, NF-κB, and inhibiting protein glycation are responsible for the drug's therapeutic effects." assertion.
- drugbank:DB05464 identifier "drugbank:DB05464" assertion.
- drugbank:DB05464 title "NOX-700" assertion.
- drugbank:DB05464 drugbank_vocabulary:x-cas cas: assertion.
- drugbank:DB05464 drugbank_vocabulary:drugbank-id "DB05464" assertion.
- drugbank:DB05464 bio2rdf_vocabulary:x-identifiers.org DB05464 assertion.
- drugbank:DB05464 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB05464" assertion.
- drugbank:DB05464 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB05464 bio2rdf_vocabulary:identifier "DB05464" assertion.