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- drugbank:DB05482 type drugbank_vocabulary:Drug assertion.
- drugbank:DB05482 label "LE-SN38 [drugbank:DB05482]" assertion.
- drugbank:DB05482 seeAlso DB05482 assertion.
- drugbank:DB05482 description "LE-SN38 is NeoPharm's NeoLipid liposomal formulation of SN-38, the active metabolite of irinotecan (Camptosar), a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. LE-SN38 is the Company's NeoLipid(R) Liposomal formulation of SN-38, the active, but poorly soluble, metabolite of Camptosar(R), a chemotherapeutic pro-drug, which is used as a first-line and second-line treatment for advanced colorectal cancer. A pro-drug is a compound that is converted into the active drug in the body. However, Camptosar(R) is converted into SN-38 in colorectal cancer cells at different rates in different patients, and this variability in conversion rates may result in suboptimal treatment. By employing the Company's proprietary NeoLipid(R) technology to directly deliver SN-38, the Company hopes to minimize treatment variability. A Phase I clinical trial was completed in 2005 and showed the potential for decreased side effects, particularly diarrhea, compared to published results of Camptosar(R). The results of that trial were presented at the American Society of Clinical Oncology (ASCO) meeting in June 2005, and were used to determine the Phase II study dose." assertion.
- drugbank:DB05482 identifier "drugbank:DB05482" assertion.
- drugbank:DB05482 title "LE-SN38" assertion.
- drugbank:DB05482 drugbank_vocabulary:x-pubchemcompound pubchem.compound:104842 assertion.
- drugbank:DB05482 drugbank_vocabulary:x-chemspider chemspider:94634 assertion.
- drugbank:DB05482 drugbank_vocabulary:x-cas cas: assertion.
- drugbank:DB05482 drugbank_vocabulary:drugbank-id "DB05482" assertion.
- drugbank:DB05482 bio2rdf_vocabulary:x-identifiers.org DB05482 assertion.
- drugbank:DB05482 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB05482" assertion.
- drugbank:DB05482 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB05482 bio2rdf_vocabulary:identifier "DB05482" assertion.
- drugbank:DB05482 drugbank_vocabulary:x-bindingdb bindingdb:50099247 assertion.